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pentobarbital decreases amounts of toremifene by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. CYP3A4 inducers boost level of toremifene metabolism, lowering the continual-state concentration in serum.pentobarbital will minimize the extent or result of tinidazole by affecting hepatic/intestinal enzyme CYP3A4 metaboli